Our research explores gene regulatory circuits and chromatin dynamics in the brain, studying how these features contribute to brain development, evolution, and function. We apply a combination of genomics, mouse and cell-based models, and human genetics. Our work is rooted in basic and translational science, with an ultimate goal of understanding the biological components of human diseases and disorders of the brain and improving clinical care of afflicted individuals. To that end, we perform both experimental work and computational analysis to reveal function of primary DNA sequence, epigenomic modifications, and chromatin structure.
- Enhancers as mediators of development, response to environment, and disease
- Chromatin and gene regulation in brain development, evolution, and function
- Genetic models of neurodevelopmental and psychiatric disorders
- Development and implementation of genomic applications in the clinic
Our main space is located at the UC Davis Center for Neuroscience
We are always looking for motivated undergraduates, graduate students, and postdocs who are interested in joining the group.