PhD student Tracy Warren’s new paper dissecting the genetic profiles of endophenotypes in psychotic disorders is out now in Molecular Psychiatry! This study, done in collaboration with Dr. Pak Sham at the University of Hong Kong and Dr. Cam Carter at UC Davis and UC Irvine, uses pathway polygenic risk scores to dissect the convergent pathways taken toward psychiatric symptoms in 205 human subjects with a psychotic disorder and 115 controls. Major findings include associations of glutamatergic and GABAergic deficits with negative symptoms and cognitive control abnormalities, as well as associations of dopaminergic deficits with improved likelihood of response to antipsychotic medications.
Read the official paper in Molecular Psychiatry or the news item published by the UC Davis College of Biological Sciences today!